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Irwin D Bernstein Selected Research

Gemtuzumab (Mylotarg)

1/2019CD33_PGx6_Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group.
1/2019ABCB1 SNP predicts outcome in patients with acute myeloid leukemia treated with Gemtuzumab ozogamicin: a report from Children's Oncology Group AAML0531 Trial.
11/2017Gemtuzumab ozogamicin for acute myeloid leukemia.
8/2017CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531.
3/2016CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531.
6/2012Acute myeloid leukemia stem cells and CD33-targeted immunotherapy.
4/2012Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML.
5/2008Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice bearing human AML xenografts.
5/2007CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy.
10/2005Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence.
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Irwin D Bernstein Research Topics

Disease

18Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2022 - 05/2003
6Neoplasms (Cancer)
11/2022 - 05/2002
3Leukemia
11/2022 - 05/2003
2Lymphoma (Lymphomas)
11/2022 - 05/2002
2Hematologic Neoplasms (Hematological Malignancy)
11/2022 - 02/2002
2Infections
01/2018 - 07/2016
2Anemia
02/2012 - 06/2008
1Inflammation (Inflammations)
01/2018
1Neutropenia
07/2016
1Hypersensitivity (Allergy)
07/2016
1Muscular Dystrophies (Muscular Dystrophy)
10/2012
1Acute Promyelocytic Leukemia
06/2012
1Leukocytosis (Pleocytosis)
02/2012
1Spinocerebellar Ataxias (Spinocerebellar Ataxia)
03/2010
1Hyperbilirubinemia
10/2005
1Medulloblastoma
11/2004
1Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
10/2003
1Non-Hodgkin Lymphoma (Lymphosarcoma)
10/2003
1Splenomegaly
05/2003
1Hepatomegaly
05/2003
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
05/2002

Drug/Important Bio-Agent (IBA)

13Gemtuzumab (Mylotarg)FDA Link
01/2019 - 08/2003
4Immunoconjugates (Immunoconjugate)IBA
08/2017 - 08/2003
2CytokinesIBA
11/2022 - 03/2010
2Proteins (Proteins, Gene)FDA Link
11/2022 - 08/2003
2LigandsIBA
10/2012 - 11/2004
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
03/2006 - 05/2002
2Monoclonal AntibodiesIBA
09/2003 - 05/2002
1Transcription Factors (Transcription Factor)IBA
11/2022
1Chimeric Antigen ReceptorsIBA
11/2022
1AntigensIBA
11/2022
1Biomarkers (Surrogate Marker)IBA
11/2022
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
07/2016
1Sirtuin 1IBA
02/2012
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
03/2010
1Core Binding Factors (Core-Binding Factor)IBA
03/2010
1Cyclin EIBA
06/2008
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
05/2007
1Busulfan (Busulfex)FDA Link
03/2006
1Alanine Transaminase (SGPT)IBA
10/2005
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
10/2005
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2004
1Gamma Secretase Inhibitors and ModulatorsIBA
11/2004
1beta-Lactamases (beta-Lactamase)IBA
09/2003
1Neoplasm Antigens (Tumor Antigens)IBA
09/2003
1EnzymesIBA
09/2003
1Phosphotransferases (Kinase)IBA
08/2003
1tyrosine receptor (receptor, tyrosine)IBA
08/2003
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
08/2003
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2003
1Surface Antigens (Surface Antigen)IBA
05/2003
1Etoposide (VP 16)FDA LinkGeneric
05/2002
1AntibodiesIBA
02/2002

Therapy/Procedure

9Therapeutics
11/2022 - 02/2002
4Transplantation
01/2018 - 05/2002
3Drug Therapy (Chemotherapy)
07/2016 - 10/2005
2Immunotherapy
06/2012 - 05/2008
2Hematopoietic Stem Cell Transplantation
10/2005 - 10/2003
2Radioimmunotherapy
10/2003 - 05/2002
1Cell Transplantation
03/2006
1Stem Cell Transplantation
05/2002